A novel complex class 1 integron found in a Klebsiella pneumoniae isolate from Portugal

Prevalence of Class 1 Integron in Klebsiella Pneumoniae Isolates from Hospitals of Sanandaj, Iran

Background and Aims: Integrons as mobile genetic elements are located on the chromosome or on a plasmid in bacteria. Integrons play a main role in the dissemination of antibiotic resistance genes among different families of bacteria. The aim of this study was to identify the prevalence of class 1 integron in Klebsiella pneumoniae isolates from hospitals of Sanandaj, Kurdistan province, Iran. M...

Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.

Klebsiella pneumoniae ORI-1 was isolated in 1998 in France from a rectal swab of a 1-month-old girl who was previously hospitalized in Cayenne Hospital, Cayenne, French Guiana. This strain harbored a ca. 140-kb nontransferable plasmid, pTK1, that conferred an extended-spectrum cephalosporin resistance profile antagonized by the addition of clavulanic acid, tazobactam, or imipenem. The gene for ...

Molecular characterization of a new class 3 integron in Klebsiella pneumoniae.

Klebsiella pneumoniae FFUL 22K was isolated in April 1999 from the urine of an intensive care unit patient in Portugal. The strain showed an extended-spectrum cephalosporin resistance profile. A typical synergistic effect between cefotaxime or cefepime and clavulanic acid was observed. An Escherichia coli transformant displayed a similar resistance phenotype and harbored a ca. 9.4-kb plasmid (p...

First report of OXA-181 and NDM-1 from a clinical Klebsiella pneumoniae isolate from Nigeria.

Class 2 integron with a novel cassette array in a Burkholderia cenocepacia isolate.

Burkholderia cepacia complex (BCC) organisms are gramnegative opportunistic emerging pathogens associated with a poor prognosis for patients with cystic fibrosis (CF) (10). Carbapenems and ceftazidime are administered to patients suffering from BCC infections, and trimethoprim-sulfamethoxazole has historically been the drug of choice (6). Recently, the acquisition of resistance determinants to ...